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Injectable Oily Solution
1 mL of solution contains:
- active substance: testosterone enanthate 500 mg;
- auxiliary substances: benzyl alcohol, peach or peanut oil.
Transparent oily solution, light yellow to yellow in color, with a characteristic odor.
SP Enanthate Forte injection, for intramuscular injection, contains Testosterone Enanthate which is insoluble in water, very soluble in ether and soluble in vegetable oils.
Androgens are derivatives of cyclopentano-perhydrophenanthrene. Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. Testosterone is the primary endogenous androgen. In it active form, SP Enanthate Forte have a 17-beta-hydroxy group. Esterification of the 17-beta-hydroxy group produces compounds (Testosterone Enanthate and Testosterone Propionate) which have a longer duration of action and are hydrolyzed in vivo to free Testosterone.
Injectable oily solution.
Androgen; anabolic steroid; androgen ester; G03B A03.
Pharmacodynamics
Testosterone Enanthate is an ester of testosterone. Testosterone is the primary androgen hormone synthesized and released by the testicles. It is responsible for the growth and development of male sexual organs and secondary sexual characteristics (maturation of the prostate, seminal vesicles, penis and scrotum), male hair distribution (face, pubis, chest), laryngeal development, body muscles and fat distribution. Retains nitrogen, sodium, potassium and phosphorus, increases anabolism and reduces protein catabolism. Premature increase in testosterone plasma levels in the prepubertal period causes the epiphyses to close and the growth to stop. Stimulates the production of erythropoietin and erythrocytes. Through the feedback mechanism it inhibits the secretion of pituitary luteinizing and folliculostimulating hormones and causes the suppression of spermatogenesis.
In women it inhibits pituitary gonadrophic function, ovarian function, mammary glands, endometrial atrophy. Due to its antagonistic action against estrogen, it is used in the treatment of uterine fibroids, endometriosis, breast cancer. Manifests beneficial action in the climacteric period.
Pharmacokinetics
Testosterone enanthate is absorbed slowly. Maximum plasma concentration is reached over 72 hours after intramuscular administration. Duration of action - 2-4 weeks. In the blood, about 98% of testosterone binds to a specific fraction of globulins, which binds testosterone and estradiol.
Biotransformation occurs in the liver to various 17-ketosteroids, which after conjugation with glucuronic or sulfuric acid are excreted in the urine (approximately 90%). Approximately 6% of the absorbed preparation is excreted in the faeces in free form.
Half life: 15-16 days
Routes ofadministration: intramuscular injection
Dosage forms: (Men): 500-1000 mg / 7 days; (Women): Not Recommended
Acne: yes
Water retention: yes (high)
High blood pressure: yes
Hepatotoxicity: no
Aromatase: yes (high, 100% of testosterone)
Progestogen activity: low
DHT (dehydrotestosterone) conversion: no
Decreased HPTA function (own testosterone production): yes (weak)
Anabolic activity: 100%
Androgenic activity: 100%
Detection time: 3 months after the last injection.
In men - hormone replacement therapy for testosterone deficiency disorders:
- retention of sexual maturation;
- eunucoidism, non-development of the genitals;
- impotence of hormonal origin;
- hypopituitarism;
- male climax symptoms (decreased libido and physical and intellectual activity);
- post-castration syndrome (androgenic deficiency after castration);
- osteoporosis caused by androgenic insufficiency.
For women:
- hyperestrogenemia, functional hemorrhages;
- uterine fibroids;
- endometriosis;
- menopause (in combination with estrogen);
- breast cancer;
- osteoporosis.
Deep intramuscular. The dose is determined individually depending on the disease, sex, age, clinical efficacy. Adults are usually given 50-200 mg intramuscularly once every 2-4 weeks. It is not recommended to exceed the dose of 400 mg per month. The duration of treatment is determined individually.
In hypogonadism in men like eunucoidism, the recommended doses are 50-400 mg every 2-4 weeks.
In case of retention of sexual maturation, 50-200 mg are administered every 2-4 weeks for 4-6 months.
In inoperable breast cancer in women: 200-400 mg every 2-4 weeks.
For bodybuilding purposes, average Dosage: men 500-1000 mg per week, women 50-100 mg. The cycle last from 8 up to 16 weeks.
The drug is not administered intravenously!
- Priapism and other symptoms of sexual hyperstimulation (frequent erection);
- in adolescents of prepubertal age - accelerating sexual development; increase in the frequency of erections, increase in the sexual organ in size, premature closure of the epiphyses;
- impaired spermatogenesis and disorders of sperm maturation, oligospermia and reduced ejaculate volume;
- prostate abnormalities;
- in women - bleeding from the genitals, increased libido; symptoms of virilization are possible with prolonged administration;
- hirsutism, gynecomastia;
- seborrhea, acne, oily skin, hair loss;
- sodium and water retention, edema;
- symptoms of hypercalcaemia;
- thrombophlebitis;
- nausea, cholestatic jaundice, increased levels of liver transaminases (normalizes when treatment is stopped);
- headache, depression, aggression, anxiety, sleep disorders, paresthesias.
Pain, pruritus and hyperemia at the injection site are possible. Common side effects are: nausea, water retention, blood pressure, acne, painful erections, vomiting, bitter taste in mouth; change in sex drive, fatigue, mouth irritation, gum tenderness or swelling, headache and aggressive behavior.
SP Enanthate Forte contains endogenous androgens, which are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include the growth and maturation of prostate, seminal vesicles, penis and scrotum; the development of male hair distribution, such as beard, pubic, chest and axillary hair; laryngeal enlargement, vocal chord thickening, alterations in body musculature, and fat distribution. SP Enanthate Forte cause retention of nitrogen, sodium, potassium, phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.
Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause a disproportionate advancement in bone maturation. Use SP Enanthate Forte over long periods may result in fusion of the epiphyseal growth center and termination of growth process.
Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.
During exogenous administration of androgens, endogenous Testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). If you buy SP Enanthate Forte and use it at large doses of , spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
Individual hypersensitivity to the drug, prostate or breast cancer; prostate hyperplasia with symptoms of urinary disorders; nephrosis or nephrotic phase of nephritis, edema; hypercalcemia; liver function disorders; diabetes; heart or coronary insufficiency, a history of myocardial infarction, atherosclerosis in elderly men; pregnancy, lactation.
In acute overdose, testosterone toxicity is quite low.
In chronic overdose it is possible to develop priapism. In this case it is necessary to stop the administration of the drug, and after the disappearance of symptoms - to resume treatment in lower doses.
In case of androgen-dependent side effects it is necessary to stop the administration of the drug. After the disappearance of the side effects, resume treatment in lower doses.
Patients with latent or overt heart failure, renal impairment, hypertension, epilepsy or migraine (or a history of these conditions) will be under constant supervision, as androgens may in some cases cause sodium and water retention. Liver function will be monitored during long-term treatment. In patients with breast cancer, hypernephroma, lung cancer with bone metastases, the level of calcium in the blood and urine will be controlled. In adolescents in the prepubertal period, androgens should be administered with caution to avoid stopping growth and premature puberty.
Increases the effectiveness of anticoagulants and antidiabetics (dose adjustment is required), inhibits the elimination of cyclosporine. Inducers of liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin) reduce the effect of testosterone.
Injectable oily solution 5000 mg / 1 mL in 10 mL vials.
Store in a dry place and away from light at 15-25 ° C. Keep out of the reach and sight of children.
It is issued with prescription.
June 2020
SP Laboratory
Europe
www.sp-laboratory.com
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TESTOSTERONE ENANTHATE 250 MG INJECTION
Drug Class: Androgen; Anabolic Steroid; Androgen Ester
Composition:
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- Concentration: 250 mg/mL
Presentation: 10 mL Vial
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TESTOSTERONE ENANTHATE 400 MG INJECTION
Drug Class: Injectable
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TESTOSTERONE ENANTHATE 400 MG INJECTION
Drug Class: Androgen; Anabolic Steroid; Androgen Ester
Composition:
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- Concentration: 400 mg/mL
Presentation: 10 mL Vial
Manufacturer: Dragon Pharma
Common Name(s): Testostroval, Testro LA, Durathate, Everone, Delatestryl, Testrin, Andro LA, Andropository
Warning! High dosed gear, can cause pain and reaction at the injection site!`
Warm high concentration 400 mg<
before administration
in order to avoid high levels of PIP
and massage afterward.
TESTOSTERONE ENANTHATE 250 MG INJECTION
Drug Class: Androgen; Anabolic Steroid; Androgen Ester
Composition:
- Active Substance: Testosterone Enanthate
- Concentration: 250 mg/mL
Presentation: 10 mL Vial
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TESTOSTERONE ENANTHATE 250 MG INJECTION
Drug Class: Androgen; Anabolic Steroid; Androgen Ester
Composition:
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Presentation: 10 Amps [1 mL per Amp]
Manufacturer: Zerox Pharmaceuticals
TESTOSTERONE ENANTHATE 250 MG INJECTION
Drug Class: Androgen; Anabolic Steroid; Androgen Ester
Composition:
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Presentation: 10 mL Vial
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USA Only Domestic Delivery
TESTOSTERONE ENANTHATE 250 MG INJECTION
Drug Class: Pharma Grade Androgen; Anabolic Steroid; Androgen Ester
Composition:
- Active Substance: Testosterone Enanthate
- Concentration: 250 mg/mL
Presentation: 10 Amps [1 mL per Amp]
Manufacturer: Balkan Pharmaceuticals
Common Name(s): Delatestryl, Testostroval,
Testro LA, Andro LA, Durathate, Everone, Testrin, Andropository
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