Testoxyl Enanthate 400

TESTOXYL ENANTHATE 400 BY KALPA PHARMACEUTICALS

Injectable Oily Solution

DRUG COMPOSITION

1 mL of solution contains:
- active substance: testosterone enanthate 400 mg;
- auxiliary substances: benzyl alcohol, peach or peanut oil.

DRUG DESCRIPTION

Transparent oily solution, light yellow to yellow in color, with a characteristic odor.

Testoxyl Enanthate 400 released by Kalpa Pharmaceuticals is an injectable steroid which is considered one of the most basic for athletes and bodybuilders worldwide. It is a long-estered compound with high anabolic and androgenic properties and offers dramatic gain in muscle size, body strength, stamina, and performance, sexual drive and libido. It improves the levels of red blood cell production promotes the increase nitrogen retention in the muscle. This compound has the ability to protect your hard earned muscle from the catabolic glucocorticoid hormones, thus inhibiting their ability to send a message to muscle cells to release stored protein. The active life of Testosterone Enanthate is approximately 5-8 days.

PHARMACEUTICAL FORM

Injectable oily solution.

PHARMACEUTICAL GROUP AND ATC CODE

Androgen; anabolic steroid; androgen ester; G03B A03.

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics
Testosterone Enanthate is an ester of testosterone. Testosterone is the primary androgen hormone synthesized and released by the testicles. It is responsible for the growth and development of male sexual organs and secondary sexual characteristics (maturation of the prostate, seminal vesicles, penis and scrotum), male hair distribution (face, pubis, chest), laryngeal development, body muscles and fat distribution. Retains nitrogen, sodium, potassium and phosphorus, increases anabolism and reduces protein catabolism. Premature increase in testosterone plasma levels in the prepubertal period causes the epiphyses to close and the growth to stop. Stimulates the production of erythropoietin and erythrocytes. Through the feedback mechanism it inhibits the secretion of pituitary luteinizing and folliculostimulating hormones and causes the suppression of spermatogenesis.

In women it inhibits pituitary gonadrophic function, ovarian function, mammary glands, endometrial atrophy. Due to its antagonistic action against estrogen, it is used in the treatment of uterine fibroids, endometriosis, breast cancer. Manifests beneficial action in the climacteric period.

Pharmacokinetics
Testosterone enanthate is absorbed slowly. Maximum plasma concentration is reached over 72 hours after intramuscular administration. Duration of action - 2-4 weeks. In the blood, about 98% of testosterone binds to a specific fraction of globulins, which binds testosterone and estradiol.

Biotransformation occurs in the liver to various 17-ketosteroids, which after conjugation with glucuronic or sulfuric acid are excreted in the urine (approximately 90%). Approximately 6% of the absorbed preparation is excreted in the faeces in free form.

PROFILE

Half life: 15-16 days
Routes ofadministration: intramuscular injection
Dosage forms: (Men): 250-500 mg / 7 days; (Women): Not Recommended
Acne: yes
Water retention: yes (high)
High blood pressure: yes
Hepatotoxicity: no
Aromatase: yes (high, 100% of testosterone)
Progestogen activity: low
DHT (dehydrotestosterone) conversion: no
Decreased HPTA function (own testosterone production): yes (weak)
Anabolic activity: 100%
Androgenic activity: 100%
Detection time: 3 months after the last injection.

THERAPEUTICAL INDICATIONS

In men - hormone replacement therapy for testosterone deficiency disorders:
- retention of sexual maturation;
- eunucoidism, non-development of the genitals;
- impotence of hormonal origin;
- hypopituitarism;
- male climax symptoms (decreased libido and physical and intellectual activity);
- post-castration syndrome (androgenic deficiency after castration);
- osteoporosis caused by androgenic insufficiency.

For women:
- hyperestrogenemia, functional hemorrhages;
- uterine fibroids;
- endometriosis;
- menopause (in combination with estrogen);
- breast cancer;
- osteoporosis.

DOSES AND METHOD OF ADMINISTRATION

Deep intramuscular. The dose is determined individually depending on the disease, sex, age, clinical efficacy. Adults are usually given 50-200 mg intramuscularly once every 2-4 weeks. It is not recommended to exceed the dose of 400 mg per month. The duration of treatment is determined individually.

In hypogonadism in men like eunucoidism, the recommended doses are 50-400 mg every 2-4 weeks.

In case of retention of sexual maturation, 50-200 mg are administered every 2-4 weeks for 4-6 months.

In inoperable breast cancer in women: 200-400 mg every 2-4 weeks.

For bodybuilding purposes, the average dosage of the compound is 250-800 mg per week for men and it is not quite recommended for women.

The drug is not administered intravenously!

SIDE EFFECTS

- Priapism and other symptoms of sexual hyperstimulation (frequent erection);
- in adolescents of prepubertal age - accelerating sexual development; increase in the frequency of erections, increase in the sexual organ in size, premature closure of the epiphyses;
- impaired spermatogenesis and disorders of sperm maturation, oligospermia and reduced ejaculate volume;
- prostate abnormalities;
- in women - bleeding from the genitals, increased libido; symptoms of virilization are possible with prolonged administration;
- hirsutism, gynecomastia;
- seborrhea, acne, oily skin, hair loss;
- sodium and water retention, edema;
- symptoms of hypercalcaemia;
- thrombophlebitis;
- nausea, cholestatic jaundice, increased levels of liver transaminases (normalizes when treatment is stopped);
- headache, depression, aggression, anxiety, sleep disorders, paresthesias.

Pain, pruritus and hyperemia at the injection site are possible. The main side effects after the use of Testosterone Enanthate are: increased serum cholesterol, irregular menstrual cycles, painful penile erections, vomiting, nausea, acne, increased blood pressure, mood swings and aggressiveness, as well as strong masculinisation effects among women.

CONTRAINDICATIONS

Individual hypersensitivity to the drug, prostate or breast cancer; prostate hyperplasia with symptoms of urinary disorders; nephrosis or nephrotic phase of nephritis, edema; hypercalcemia; liver function disorders; diabetes; heart or coronary insufficiency, a history of myocardial infarction, atherosclerosis in elderly men; pregnancy, lactation.

OVERDOSE

In acute overdose, testosterone toxicity is quite low.

In chronic overdose it is possible to develop priapism. In this case it is necessary to stop the administration of the drug, and after the disappearance of symptoms - to resume treatment in lower doses.

WARNINGS AND SPECIAL PRECAUTIONS FOR USE

In case of androgen-dependent side effects it is necessary to stop the administration of the drug. After the disappearance of the side effects, resume treatment in lower doses.

Patients with latent or overt heart failure, renal impairment, hypertension, epilepsy or migraine (or a history of these conditions) will be under constant supervision, as androgens may in some cases cause sodium and water retention. Liver function will be monitored during long-term treatment. In patients with breast cancer, hypernephroma, lung cancer with bone metastases, the level of calcium in the blood and urine will be controlled. In adolescents in the prepubertal period, androgens should be administered with caution to avoid stopping growth and premature puberty.

INTERACTIONS WITH OTHER DRUGS

Increases the effectiveness of anticoagulants and antidiabetics (dose adjustment is required), inhibits the elimination of cyclosporine. Inducers of liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin) reduce the effect of testosterone.

Testoxyl Enanthate 400 is typically stacked with anabolic steroids as Anavar, Clenbuterol, Winstrol 10, Deca Durabolin, Boldenone, and Primobolan during cycles and with anti-estrogens compounds like Clomid, Arimidex, or Nolvadex during post cycle therapy. An average testosterone enanthate cycle lasts about 10 weeks.

PRESENTATION, PACKAGING

Injectable oily solution 300 mg / 1 mL in 10 mL vials.

STORAGE

Store in a dry place and away from light at 15-25 ° C. Keep out of the reach and sight of children.

LEGAL STATUS

It is issued with prescription.

DATE OF LAST TEXT CHECKS

December 2024

NAME AND ADDRESS OF THE MANUFACTURER

Kalpa Pharmaceuticals
India
www.kalpapharmaceuticals.com

EXTERNAL LINKS

Testosterone Enanthate >> Wikipedia

Kalpa Pharmaceuticals Reviews >> AZSteroids

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