PE 22-28 10 mg

Dragon Pharma PE 22-28 10 mg: PACAP-Derived Neuropeptide for Research

Dragon Pharma introduces its specialized research peptide, PE 22-28 10 mg, a compound derived from the C-terminal fragment of pituitary adenylyl cyclase-activating polypeptide (PACAP 1–38). With the sequence Gly-Ile-Ala-Gly-Ala-Ser-Asp-Arg, this lyophilized powder in a 2 mL vial serves as a precise tool for investigating targeted neuropeptide signaling pathways. As a selective PAC1 receptor agonist, PE 22-28 facilitates the study of cAMP accumulation and downstream CREB phosphorylation, key mechanisms in neural plasticity and cellular adaptation. Scientific literature, including reviews on PACAP signaling and neuroprotection, underscores the significance of this pathway. Dragon Pharma ensures this product meets exacting standards of purity and stability, providing researchers with a reliable compound for advanced neuroscientific and cognitive function studies.

Effects of PE 22-28 10 mg

The primary research interest in PE 22-28 stems from its targeted modulation of the PAC1 receptor, leading to a cascade of intracellular events with observable outcomes in preclinical models. Its effects are primarily studied in the context of neural and cognitive systems, rather than direct metabolic or anabolic pathways. Key research observations include:

• Neurotrophic Support & Plasticity: By activating pathways involving cAMP and CREB, PE 22-28 is studied for its potential role in supporting neuron survival, differentiation, and synaptic plasticity—the foundation of learning and memory models.
• Neuroprotective Mechanisms: Research investigates its capacity to modulate cellular responses to oxidative stress and excitotoxicity, making it a compound of interest for studies on neural injury or degeneration.
• Modulation of Neurotransmitter Systems: Indirect effects on the release and function of key neurotransmitters like dopamine, serotonin, and acetylcholine are explored, linking it to research on mood, focus, and cognitive processing.
• Cellular Energy Metabolism in Neurons: The PACAP pathway is implicated in regulating neuronal energy homeostasis, a growing area of research for cognitive endurance and fatigue.

These effects position PE 22-28 as a niche but powerful tool for cognitive and neurological research, not for direct performance enhancement.

Recommended Dosage & Reconstitution for Research

PE 22-28 is a research chemical, and all dosing guidelines are strictly for controlled laboratory studies. The 10 mg vial should be reconstituted with bacteriostatic water or sterile saline. A standard research dilution is 1 mL of diluent, yielding a concentration of 10 mg/mL, though 2 mL can be used for more precise, lower concentration dosing. In experimental models, dosing is typically low and based on micrograms per kilogram of body weight (µg/kg), administered via subcutaneous or intraperitoneal injection. Due to its peptide nature and focus on central nervous system pathways, research protocols often utilize once-daily or even every-other-day administration to study cumulative effects on neural signaling. Extreme precision in measurement and aseptic technique is non-negotiable for valid results.

Potential Research Cycles & Experimental Stacking

Given its mechanism, PE 22-28 is often studied in medium to long-term cycles (e.g., 4-12 weeks) to observe effects on neural plasticity and adaptation. For comprehensive studies on cognitive performance, recovery, and overall system optimization, researchers may design protocols that stack PE 22-28 with other compounds to investigate synergistic or complementary pathways. The following are examples of such experimental design concepts:

• For Cognitive & Memory Studies: Research may combine PE 22-28 with other nootropic peptides like Selank 10 mg or Semax 5mg to model complex interactions in learning, memory formation, and anxiety-related behaviors.
• For Neural Recovery & Repair Models: Studies on nerve injury or protection might stack it with established recovery peptides such as BPC 157 or SS-31 50 mg (for mitochondrial support in neurons).
• For Sleep & Recovery Optimization: To study the intersection of neural recovery and sleep quality, researchers might examine combinations with DSIP 10 mg (Delta Sleep-Inducing Peptide).
• For Broader Hormonal & Cognitive Interaction: Advanced models might investigate how neural pathways modulated by PE 22-28 interact with hormonal environments influenced by compounds like Testagen 20 mg or during post-cycle therapy with Enclomiphene.

These stacks are complex and require controlled conditions to isolate the effects of each variable.

Possible Side Effects & Research Considerations

In preclinical research settings, PE 22-28 is generally associated with a mild side effect profile due to its targeted receptor activity. However, responsible study design must account for potential adverse reactions. These may include transient changes in behavior (e.g., altered activity levels, anxiety-like or sedation responses in animal models) due to its central nervous system activity. Autonomic effects like minor, transient fluctuations in heart rate or blood pressure have been noted in some studies. The primary risks in a laboratory context remain technical: infection from non-sterile technique, inaccurate dosing leading to unreliable data, and the ethical considerations of manipulating complex neural pathways. Researchers must have appropriate oversight and monitoring protocols in place.

Mechanism of Action & Research Significance

PE 22-28's value lies in its specific mechanism. It binds to the PAC1 receptor, a G-protein coupled receptor prominently expressed in the brain and nervous system. This binding activates adenylate cyclase, increasing intracellular cyclic AMP (cAMP). Elevated cAMP then activates protein kinase A (PKA), which phosphorylates the transcription factor CREB (cAMP response element-binding protein). Phosphorylated CREB translocates to the nucleus and promotes the transcription of genes involved in neuronal survival, plasticity (like BDNF), and metabolic adaptation. This direct line from receptor activation to gene expression makes it an excellent model for studying how specific signaling cascades influence long-term neural function and adaptation.

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